TfR1 Internalization (Early-endosome specific) Cell
CBP74674
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| I. Background | |
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TfR1（转铁蛋白受体1）是细胞摄取铁的核心受体，顺利获得受体介导的内吞作用将结合了铁的转铁蛋白转运入细胞，维持细胞内铁稳态，对红细胞生成和免疫细胞功能至关重要。它在多种癌细胞中高表达，也是血脑屏障转运和肿瘤靶向研究的热点靶点。 |
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| II. Description | |
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TfR1 Internalization (Early-endosome specific) Cell 药靶模型很好的模拟了体内 TfR1 的信号转导过程。 |
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| III. Introduction | |
| Expressed gene: | TfR1 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | McCoy's 5a +10%FBS +2 μg/ml Puromycin +5 μg/ml Blasticidin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
IV. Representative Data Figure 1. Dose Response of Trontinemab in TfR1 Internalization (Early-endosome specific) Cell (C15). |
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